反应详情

To a solution of methyl 3-hydroxybenzoate (5.0 g, 32.9 mmol) in DMF (20 mL) was added allyl iodide (6.62 g, 39.4 mmol) followed by sodium hydride (60% oil dispersion, 0.95 g, 39.4 mmol). After stirring at rt for 5 h, the reaction mixture was quenched with H2O, extracted with ethyl acetate (three times), dried over MgSO4 and concentrated under vacuum. Purification by silica gel chromatography (10% EtOAc/hexanes) afforded the desired product.

1. customthe reaction mixture was quenched with H2O
2. extractionextracted with ethyl acetate (three times)
3. dry with materialdried over MgSO4
4. concentrationconcentrated under vacuum
5. customPurification by silica gel chromatography (10% EtOAc/hexanes)