HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → Spiro[2.5]octan-6-one oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 1-(3-Isopropoxybenzyl)-2-methylpiperidin-4-one | HCID 66790385 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | Spiro[2.5]octan-6-one oxime | HCID 57336623 | — |
Reaction Steps
To a solution containing 2.1 g (16.9 mmol) of the ketone from step 3 in 10 mL of ethanol was added 2.0 g (28.7 mmol) of hydroxylamine hydrochloride followed by 4.0 g (29 mmol) of NaOAc in 20 mL of water. The resulting mixture was refluxed for 3 h, cooled and concentrated to one-half volume and the precipitate was collected.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08211904B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-7694932913324680962f869d4b06041d |
| Source note | uspto-grants-2012_07 |