反应详情

To a solution containing 2.1 g (16.9 mmol) of the ketone from step 3 in 10 mL of ethanol was added 2.0 g (28.7 mmol) of hydroxylamine hydrochloride followed by 4.0 g (29 mmol) of NaOAc in 20 mL of water. The resulting mixture was refluxed for 3 h, cooled and concentrated to one-half volume and the precipitate was collected.

1. temperatureThe resulting mixture was refluxed for 3 h
2. temperaturecooled
3. concentrationconcentrated to one-half volume
4. customthe precipitate was collected