HCID 69081370, compound → HCID 21226128, compound

HRID 1510221Notes

Reaction equation

HRID 1510221 reaction equation
[C:1]1([N:7]([CH2:14][C:15]([O:17][CH2:18][C:19]2C=CC=CC=2)=[O:16])[CH2:8][C:9]([O:11]CC)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Pd]>[CH2:18]([O:17][C:15](=[O:16])[CH2:14][N:7]([CH2:8][C:9]([OH:11])=[O:10])[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH3:19]

Participants

4

Reactant 1

HCID 69081370HCID 69081370, compound

Product 1

HCID 21226128HCID 21226128, compoundYield 96.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Benzyl ethyl 2,2′-(phenylimino)diacetate (1.0 g) was dissolved in methanol (15 mL) and 10% palladium on carbon (100 mg) was added to the mixture. The mixture was stirred at ambient temperature for 3 hours under hydrogen atmosphere (3 atms) and filtered through bed of celite. The filtrate was concentrated in vacuo to afford [(2-ethoxy-2-oxoethyl)(phenyl)amino]acetic acid (0.698 g) as a brown oil.

Workup

  1. filtrationfiltered through bed of celite
  2. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-625790e864644c5aa6cf531738709d0e
Source dataset
uspto-grants-2012_07
Patent number
US08211919B2

Reaction notes

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