Hydrochloric Acid → 928322-40-1

HRID 1510235Notes

Reaction equation

HRID 1510235 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([CH:8]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:9]([O:11]CC)=[O:10])[CH2:4][CH2:3]1.[ClH:20]>>[ClH:20].[OH:1][CH:2]1[CH2:3][CH2:4][N:5]([CH:8]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:9]([OH:11])=[O:10])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86629752HCID 86629752, compound

Product 1

HCID 50988803928322-40-1

Procedure

A suspension of ethyl (4-hydroxypiperidin-1-yl)(phenyl)acetate (5.2 g) in 6N hydrochloric acid (80 mL) was refluxed for 14 hours and the mixture was evaporated in vacuo. The residue was triturated with methanol and collected by filtration and dried in vacuo to afford (4-hydroxypiperidin-1-yl) (phenyl)acetic acid hydrochloride (4.65 g) as a powder.

Workup

  1. temperaturewas refluxed for 14 hours
  2. customthe mixture was evaporated in vacuo
  3. customThe residue was triturated with methanol
  4. filtrationcollected by filtration
  5. customdried in vacuo

Sources & evidence

ORD record
ord-3b136036407546e98f5087189c191397
Source dataset
uspto-grants-2012_07
Patent number
US08211919B2

Reaction notes

Loading…