反应详情

To a stirred suspension of (4-nitrophenyl)boronic acid (1.6 g), 4-chloro-3fluoropyridine (1.11 g), and tetrakis (triphenylphosphine) palladium (462 mg) in 1,2-dimethoxyethane (25 mL) was added 0.8M potassium carbonate aqueous solution (25 mL) and the mixture was refluxed under nitrogen for 20 hours. After cooling, 1,2-dimethoxyethane was removed in vacuo. To the residue was added ethyl acetate, washed with water, dried over magnesium sulfate, and concentrated to afford 3-fluoro-4-(4-nitrophenyl)pyridine (2.23 g) as a brown solid.

1. temperaturethe mixture was refluxed under nitrogen for 20 hours
2. temperatureAfter cooling
3. custom1,2-dimethoxyethane was removed in vacuo
4. additionTo the residue was added ethyl acetate
5. washwashed with water
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated