Hydrochloric Acid → HCID 57663935, compound

HRID 1510247Notes

Reaction equation

HRID 1510247 reaction equation
C([O:3][C:4](=[O:29])[CH2:5][N:6]([CH2:13][C:14](=[O:28])[NH:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)=[CH:18][CH:17]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.[OH-].[Na+].Cl>CO>[O:28]=[C:14]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:23]=[CH:24][N:25]=[CH:26][CH:27]=2)=[CH:18][CH:17]=1)[CH2:13][N:6]([CH2:5][C:4]([OH:29])=[O:3])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 131729801HCID 131729801, compound

Product 1

HCID 57663935HCID 57663935, compoundYield 65.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of ethyl[(2-oxo-2-{[4-(4-pyridinyl)phenyl]amino}ethyl)(phenyl)amino]acetate (40.8 mg) in methanol (0.60 mL) was added 1N sodium hydroxide aqueous solution (0.157 mL) at ambient temperature and the mixture was stirred at ambient temperature overnight. The mixture was neutralized with 1N hydrochloric acid and the precipitate was collected by filtration. The solid was washed with n-hexane/ethyl acetate (1:1, 1.0 mL) to afford [(2-oxo-2-{[4-(4-pyridinyl)phenyl]amino}ethyl) (phenyl)amino]acetic acid (24.8 mg) as white crystals.

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washThe solid was washed with n-hexane/ethyl acetate (1:1, 1.0 mL)

Sources & evidence

ORD record
ord-c8e7f3403991480e940dea1bb6482b48
Source dataset
uspto-grants-2012_07
Patent number
US08211919B2

Reaction notes

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