2-Chloro-5-nitropyridine → 5'-nitro-4-(3-triflouromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl

HRID 1510260ノート

反応式

HRID 1510260 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.Cl.[F:12][C:13]([F:27])([F:26])[C:14]1[CH:15]=[C:16]([CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:17]=[CH:18][CH:19]=1.C(N(C(C)C)CC)(C)C>CN(C=O)C>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:23]2[CH2:24][CH2:25][CH:20]([C:16]3[CH:17]=[CH:18][CH:19]=[C:14]([C:13]([F:12])([F:26])[F:27])[CH:15]=3)[CH2:21][CH2:22]2)=[N:3][CH:4]=1)([O-:10])=[O:9]

参加物

5

反応物 3

HCID 783082-Chloro-5-nitropyridineHCID 81531DiisopropylethylamineHCID 222528494-(3-Trifluoromethylphenyl)piperidine, HCl

生成物 1

HCID 674357105'-nitro-4-(3-triflouromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

To a mixture of 2-chloro-5-nitropyridine (500 mg, 3.2 mmol) and 4-(3-trifluoromethyl-phenyl)-piperidine hydrochloride in DMF (15 mL) was added diisopropylethylamine (1.70 mL, 9.60 mmol). The mixture was heated in a sealed tube at 80° C. for 24 hours. The mixture was concentrated to dryness and triturated in methanol to give 5′-nitro-4-(3-triflouromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl. The NMR spectrum obtained on the sample is compatible with its structure.

後処理

  1. concentrationThe mixture was concentrated to dryness
  2. customtriturated in methanol

出典と根拠

ORDレコード
ord-e7cd920c181047d0ab99ade5893f496e
出典データセット
uspto-grants-2012_07
特許番号
US08211914B2

反応ノート

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