反应详情

温度

80 °C

To a mixture of 2-chloro-5-nitropyridine (500 mg, 3.2 mmol) and 4-(3-trifluoromethyl-phenyl)-piperidine hydrochloride in DMF (15 mL) was added diisopropylethylamine (1.70 mL, 9.60 mmol). The mixture was heated in a sealed tube at 80° C. for 24 hours. The mixture was concentrated to dryness and triturated in methanol to give 5′-nitro-4-(3-triflouromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl. The NMR spectrum obtained on the sample is compatible with its structure.

1. concentrationThe mixture was concentrated to dryness
2. customtriturated in methanol