Phenylboronic Acid → HCID 59637258, compound

HRID 1510306Notes

Reaction equation

HRID 1510306 reaction equation
[CH3:1][O:2][CH2:3][C@H:4]([CH3:22])[O:5][C:6]1[CH:7]=[C:8]([CH:12]=[C:13]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:14]=1)[C:9]([OH:11])=O.C1(B(O)O)C=CC=CC=1.[NH2:32][C:33]1[S:34][CH:35]=[C:36]([CH2:38][C:39]([O:41][CH2:42][CH3:43])=[O:40])[N:37]=1>>[CH2:42]([O:41][C:39](=[O:40])[CH2:38][C:36]1[N:37]=[C:33]([NH:32][C:9](=[O:11])[C:8]2[CH:7]=[C:6]([O:5][C@@H:4]([CH3:22])[CH2:3][O:2][CH3:1])[CH:14]=[C:13]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:12]=2)[S:34][CH:35]=1)[CH3:43]

Participants

4

Reactant 3

HCID 66827Phenylboronic AcidHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 58265885HCID 58265885, compound

Product 1

HCID 59637258HCID 59637258, compound

Procedure

{2-[3-phenoxy-5-((S)-2-methoxy-1-methyl-ethoxy)-benzoylamino]-thiazol-4-yl}-acetic acid ethyl ester was prepared from 3-{(1S)-2-methoxy-(methylethyl)oxy}-5-phenyloxy-benzoic acid (prepared in analogy to the method described in general synthetic descriptions, using phenylboronic acid in step D) and ethyl 2-aminothiazol-4-ylacetate following synthetic description A.

Workup

  1. customprepared in analogy to the method

Sources & evidence

ORD record
ord-d043ecf15af94e3faa37542899ec3903
Source dataset
uspto-grants-2012_07
Patent number
US08211925B2

Reaction notes

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