HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 86649454, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester | HCID 70670 | — |
| Reactant | N-(5-Formylthiazol-2-yl)-3-isopropoxy-5-phenoxybenzamide | HCID 86649453 | — |
| Product | HCID 86649454 | HCID 86649454 | 67% |
Reaction Steps
3-[2-(3-Isopropoxy-5-phenoxybenzoylamino)-thiazol-5-yl]-acrylic acid ethyl ester (102 mg, 67%) was prepared from N-(5-formylthiazol-2-yl)-3-isopropoxy-5-phenoxybenzamide (130 mg, 0.34 mmol) and (carboethoxymethylene)triphenylphospho-rane (150 mg, 0.43 mmol) by heating a THF solution (5.0 mL) of the reactants at 50° C. overnight. Molecular sieves (4A) were added to remove any water in the reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08211925B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-5ac9e02e72a342d2b9035e65ada14bfe |
| Source note | uspto-grants-2012_07 |