反应详情

3-[2-(3-Isopropoxy-5-phenoxybenzoylamino)-thiazol-5-yl]-acrylic acid ethyl ester (102 mg, 67%) was prepared from N-(5-formylthiazol-2-yl)-3-isopropoxy-5-phenoxybenzamide (130 mg, 0.34 mmol) and (carboethoxymethylene)triphenylphospho-rane (150 mg, 0.43 mmol) by heating a THF solution (5.0 mL) of the reactants at 50° C. overnight. Molecular sieves (4A) were added to remove any water in the reaction.

1. customto remove any water
2. customin the reaction