HCID 54459059, compound → tert-Butyl 5-amino-2,3-dihydro-1H-indole-1-carboxylate

HRID 1510316Notes

Reaction equation

HRID 1510316 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:8][CH2:7]2)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:8][CH2:7]2

Participants

4

Reactant 1

HCID 54459059HCID 54459059, compound

Product 1

HCID 22240520tert-Butyl 5-amino-2,3-dihydro-1H-indole-1-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

6.8 g tert-butyl 5-nitro-2,3-dihydro-indole-1-carboxylate are dissolved in 120 ml of methanol. To this are added 600 mg of palladium on charcoal (10%) and the mixture is hydrogenated for 1.5 hours at ambient temperature. Then the catalyst is filtered off and the solvent is eliminated in vacuo.

Workup

  1. filtrationThen the catalyst is filtered off

Sources & evidence

ORD record
ord-25a0ea49216342beb233ffc85c15111c
Source dataset
uspto-grants-2012_07
Patent number
US08211923B2

Reaction notes

Loading…