HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 5-nitroindoline-1-carboxylate → tert-Butyl 5-amino-2,3-dihydro-1H-indole-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 5-nitroindoline-1-carboxylate | HCID 54459059 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-Butyl 5-amino-2,3-dihydro-1H-indole-1-carboxylate | HCID 22240520 | — |
Reaction Steps
6.8 g tert-butyl 5-nitro-2,3-dihydro-indole-1-carboxylate are dissolved in 120 ml of methanol. To this are added 600 mg of palladium on charcoal (10%) and the mixture is hydrogenated for 1.5 hours at ambient temperature. Then the catalyst is filtered off and the solvent is eliminated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08211923B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-25a0ea49216342beb233ffc85c15111c |
| Source note | uspto-grants-2012_07 |