3,5-dichloro-N-(1-methyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-phenylsulphonamide → 5-Amino-1-methyl-2-oxoindoline

HRID 1510317Notes

Reaction equation

HRID 1510317 reaction equation
ClC1C=C(S([NH:12][C:13]2[CH:14]=[C:15]3[C:19](=[CH:20][CH:21]=2)[N:18]([CH3:22])[C:17](=[O:23])[CH2:16]3)(=O)=O)C=C(Cl)C=1>CO>[NH2:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[N:18]([CH3:22])[C:17](=[O:23])[CH2:16]2

Participants

3

Reactant 1

HCID 594465333,5-dichloro-N-(1-methyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-phenylsulphonamide

Product 1

HCID 226924705-Amino-1-methyl-2-oxoindoline

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction is carried out in methanol. The crude product is further reacted directly in V (5).

Sources & evidence

ORD record
ord-188f16347e2d4126b658ee9cf10e8665
Source dataset
uspto-grants-2012_07
Patent number
US08211923B2

Reaction notes

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