1-Isothiocyanato-3-(trifluoromethyl)benzene → HCID 86647224, compound

HRID 1510337Notes

Reaction equation

HRID 1510337 reaction equation
[S:1]1[CH2:5][CH2:4][N:3]=[C:2]1[NH:6][CH:7]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:18]=1[Cl:24])[CH2:8][C:9]1[CH:14]=[C:13]([CH3:15])[CH:12]=[C:11]([CH3:16])[CH:10]=1.[N:25]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([C:34]([F:37])([F:36])[F:35])[CH:29]=1)=[C:26]=[S:27]>C(Cl)(Cl)Cl>[F:35][C:34]([F:36])([F:37])[C:30]1[CH:29]=[C:28]([NH:25][C:26]([N:3]2[CH2:4][CH2:5][S:1][C:2]2=[N:6][CH:7]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:18]=2[Cl:24])[CH2:8][C:9]2[CH:10]=[C:11]([CH3:16])[CH:12]=[C:13]([CH3:15])[CH:14]=2)=[S:27])[CH:33]=[CH:32][CH:31]=1

Participants

4

Reactant 2

HCID 1372321-Isothiocyanato-3-(trifluoromethyl)benzeneHCID 25002901HCID 25002901, compound

Product 1

HCID 86647224HCID 86647224, compoundYield 53.7%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 1-(4,5-dihydrothiazol-2-yl)amino-1-(2,3-dichlorophenyl)-2-(3,5-dimethylphenyl)-ethane (0.25 g) in chloroform (10 ml) was treated with 1-isothiocyanato-3-trifluoromethylbenzene (0.13 g) at room temperature overnight. The solvent was evaporated in vacuo and the remainder was purified by column chromatography to yield 0.20 g of the title compound.

Workup

  1. customThe solvent was evaporated in vacuo
  2. customthe remainder was purified by column chromatography

Sources & evidence

ORD record
ord-779a171b7f5e4b1da2c82630c09584fd
Source dataset
uspto-grants-2012_07
Patent number
US08211924B2

Reaction notes

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