反应详情

温度

80 °C

A mixture of 2,4,6-trichloropyrimidine (1.8 g, 9.8 mmol), 5-isopropyl-1H-pyrazol-3-ylamine (1.25 g, 10.0 mmol), diisopropylethylamine (3 mL, 18 mmol) and 1-butanol (10 mL) was heated to 80° C. for 2 h, at which point LC/MS indicated that the reaction was complete. The solvents were removed on a rotary evaporator and the paste was treated with ethyl acetate. The organic solution was washed with water and brine and dried over magnesium sulfate. The residue was concentrated on a rotary evaporator, and the pale yellow solid that remained was purified via flash chromatography to yield the desired product (2.3 g, 70%) as an off white solid.

1. customThe solvents were removed on a rotary evaporator
2. additionthe paste was treated with ethyl acetate
3. washThe organic solution was washed with water and brine
4. dry with materialdried over magnesium sulfate
5. concentrationThe residue was concentrated on a rotary evaporator
6. customthe pale yellow solid that remained was purified via flash chromatography