HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1510404Generated: November 1, 2026
Diisopropylethylamine → 5-bromo-2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine
https://huagongshe.com/reaction/1510404
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Bromo-2,4-dichloropyrimidine | HCID 289973 | — |
| Reactant | 3-cyclopropyl-1H-pyrazol-5-amine | HCID 2758014 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 5-bromo-2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine | HCID 57866446 | 75% |
Reaction Steps
A mixture of 5-bromo-2,4-dichloropyrimidine (15.4 g, 67.6 mmol), 5-cyclopropyl-1H-pyrazol-3-ylamine (10.0 g, 81.3 mmol) and diisopropylethylamine (17 mL, 102 mmol) in 1-butanol (150 mL) was heated to 80° C. for 1 h. The solid that formed was collected by filtration and washed with acetonitrile to give the desired product (15.8 g, 75%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08211929B2 |
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| Source dataset | uspto-grants-2012_07 |
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| ORD ID | ord-60f9d599bbde419b96dc3728f62c00d4 |
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| Source note | uspto-grants-2012_07 |
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