反应详情

A mixture of ethyl 4-chloro-5-(4-chlorophenyl)isoxazole-3-carboxylate (20 mg, 0.07 mmol) and 4-aminotetrahydropyran (83 μL, 0.7 mmol) in absolute ethanol (1 mL) was heated to reflux for 36 hours. The volatiles were removed in vacuo and the resulting residue was purified by silica gel chromatography, eluting with dichloromethane, to afford the title compound: (16.8 mg, 0.05 mmol).

1. temperaturewas heated
2. temperatureto reflux for 36 hours
3. customThe volatiles were removed in vacuo
4. customthe resulting residue was purified by silica gel chromatography
5. washeluting with dichloromethane