Oxalic Acid → HCID 86643432, compound

HRID 1510819Notes

Reaction equation

HRID 1510819 reaction equation
[CH3:1][N:2]([CH2:22][C@@H:23]1[C:26]2[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:25]=2[CH2:24]1)[CH2:3][CH2:4][CH2:5][N:6]1[C:16](=[O:17])[CH2:15][C:14]2[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=2)[CH2:8][CH2:7]1.[C:35]([OH:40])(=[O:39])[C:36]([OH:38])=[O:37]>C(OCC)(=O)C.CC(C)=O>[CH3:1][N:2]([CH2:22][C@@H:23]1[C:26]2[CH:27]=[C:28]([O:33][CH3:34])[C:29]([O:31][CH3:32])=[CH:30][C:25]=2[CH2:24]1)[CH2:3][CH2:4][CH2:5][N:6]1[C:16](=[O:17])[CH2:15][C:14]2[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=2)[CH2:8][CH2:7]1.[C:35]([O-:40])(=[O:39])[C:36]([O-:38])=[O:37]

Participants

5

Reactant 2

HCID 971Oxalic AcidHCID 132999Ivabradine

Product 1

HCID 86643432HCID 86643432, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 8857Ethyl AcetateSolvent

Procedure

Ivabradine (44 g) was dissolved in ethyl acetate (700 ml) and to this oxalic acid (22 g) in acetone (50 ml) was added slowly and stirred for 3-4 hours at ambient temperature. The ivabradine oxalate, thus obtained was filtered, washed with ethyl acetate (100 ml) and recrystallized in acetonitrile (350 ml). XRD pattern shows that isolated ivabradine oxalate was crystalline in nature and depicted in FIG. 2.

Workup

  1. additionwas added slowly

Sources & evidence

ORD record
ord-9f64db60b33c43bd94582facc67be089
Source dataset
uspto-grants-2012_07
Patent number
US08212026B2

Reaction notes

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