HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 5-chloro-thiophene-2-carboxylic acid-N-{1-[3-methyl-4-(4-ethyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (4-Aminophenyl)(4-ethylpiperazin-1-yl)methanone | HCID 1132820 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 2-[(5-Chloro-thiophene-2-carbonyl)-amino]-propionic acid | HCID 43239338 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-chloro-thiophene-2-carboxylic acid-N-{1-[3-methyl-4-(4-ethyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide | HCID 68637187 | — |
Reaction Steps
200 μl of a 0.05-molar solution of 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid, which additionally contains 0.05 mol/l DIPEA, in DMF are combined with 100 μl of a 0.1-molar solution of HATU in DMF on a microtitre plate and mixed for 10 min on a shaker. Then 200 μl of a 0.05-molar solution of 4-(4-ethyl-piperazin-1-yl-carbonyl)-aniline which additionally contains 0.05 mol/l DIPEA are pipetted in and the mixture is again combined by jogging. After 16 h at 80° C. the mixture is filtered through basic aluminium oxide and washed again with DMF/methanol=9:1. Then it is evaporated down i. vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732466B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-f7acfaafafa34177ad495bcd78f243fe |
| Source note | uspto-grants-2010_06 |