Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4,6-dichloro-N-[(2R)-2-phenylpropyl]-1,3,5-triazin-2-amine | HCID 86644392 | — |
| Reactant | HCID 178497940 | HCID 178497940 | — |
| Product | HCID 178497939 | HCID 178497939 | — |
Reaction Steps
Methyl 4-({[(cis-4-aminocyclohexyl)carbonyl]amino}methyl)benzoate (1.48 g, 3.67 mmol, 1.00 equiv) was added to the suspension prepared in step a. The resulting mixture was heated to 40° C. and treated with 1 N NaOH to maintain a pH of 9-10. The reaction mixture was stirred for 30 min and then used immediately in the next step without workup or purification. MS (ES+): m/e 537.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08212032B2 |
|---|
| Source dataset | uspto-grants-2012_07 |
|---|
| ORD ID | ord-76ff7c203c264abbaf7c52ce8d227571 |
|---|
| Source note | uspto-grants-2012_07 |
|---|
