反应详情

温度

60 °C

A mixture of N4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)pyridine-3,4-diamine (0.0650 g, 0.20 mmol), triethyl orthoformate (5.0 ml, 30 mmol), and p-TsOH (0.0039 g, 0.020 mmol) was heated at 60° C. After 2 h reaction is complete. Reaction was concentrated. Took up in DMSO and purified on RPHPLC. Fractions containing product were treated with 91 sodium carbonate and volatiles removed. Collected product by filtration. MS m/z=328.1 [M+1]+. Calc'd for C18H13N7: 327.3.

1. customAfter 2 h reaction
2. customReaction
3. concentrationwas concentrated
4. custompurified on RPHPLC
5. additionFractions containing product
6. additionwere treated with 91 sodium carbonate and volatiles
7. customremoved
8. filtrationCollected product by filtration