反应详情

The isoquinoline of step 2 was dissolved in phosphorus oxychloride (2.5 mL) and heated at reflux for 1 hour. The excess phosphorus oxychloride was removed under reduced pressure and the residue was dissolved in chloroform. The resulting solution was washed with 1N aq. sodium hydroxide, water and brine. Evaporation of the solvent under reduced pressure gave crude 1-chloro-6-methoxy-3-methylisoquinoline, which was used directly in the next step.

1. temperatureheated
2. temperatureat reflux for 1 hour
3. customThe excess phosphorus oxychloride was removed under reduced pressure
4. dissolutionthe residue was dissolved in chloroform
5. washThe resulting solution was washed with 1N aq. sodium hydroxide, water and brine
6. customEvaporation of the solvent under reduced pressure