Ethyl formate → HCID 86639223, compound

HRID 1511614Notes

Reaction equation

HRID 1511614 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11].[CH:15](OCC)=[O:16]>C1(C)C=CC=CC=1>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][N:7]([CH:15]=[O:16])[CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11]

Participants

4

Reactant 2

HCID 8025Ethyl formateHCID 14896429N-(2-Thienylmethyl)-β-alanine ethyl ester

Product 1

HCID 86639223HCID 86639223, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Ethyl 3-[(thiophen-2-ylmethyl)amino]propionate (13.8 g) prepared in the step 1 and 47.8 g of ethyl formate were dissolved in 100 mL of toluene and heated to reflux overnight. After the reaction solution was cooled, the solvent was evaporated therefrom in vacuo to give 15.6 g of the objective compound as light yellow liquid.

Workup

  1. temperatureheated
  2. temperatureto reflux overnight
  3. temperatureAfter the reaction solution was cooled
  4. customthe solvent was evaporated

Sources & evidence

ORD record
ord-bc2babd608984d479558c4097b7a0a7d
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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