1-Fluoro-3-nitrobenzene → 5-Methyl-7-(3-nitrophenyloxy)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

HRID 1511622Notes

Reaction equation

HRID 1511622 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]([OH:8])[C:5]2[S:9][CH:10]=[CH:11][C:4]=2[CH2:3]1.F[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[CH:14]=1>>[CH3:1][N:2]1[CH2:7][CH:6]([O:8][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[CH:14]=2)[C:5]2[S:9][CH:10]=[CH:11][C:4]=2[CH2:3]1

Participants

3

Reactant 2

HCID 98231-Fluoro-3-nitrobenzeneHCID 203668405-Methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol

Product 1

HCID 684118765-Methyl-7-(3-nitrophenyloxy)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Procedure

The same method as in Example 1 was conducted using 5-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 14) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and 1-fluoro-3-nitro benzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-22c407eb762840b4a7c854b880fdccd5
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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