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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1511622Generated: November 4, 2026

1-Fluoro-3-nitrobenzene → 5-Methyl-7-(3-nitrophenyloxy)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

https://huagongshe.com/reaction/1511622

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Fluoro-3-nitrobenzeneHCID 9823—
Reactant5-Methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-olHCID 20366840—
Product5-Methyl-7-(3-nitrophenyloxy)-4,5,6,7-tetrahydrothieno[3,2-c]pyridineHCID 68411876—

Reaction Steps

The same method as in Example 1 was conducted using 5-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 14) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and 1-fluoro-3-nitro benzene instead of 1-fluoronaphthalene to give the objective compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217031B2
Source datasetuspto-grants-2012_07
ORD IDord-22c407eb762840b4a7c854b880fdccd5
Source noteuspto-grants-2012_07