1,2-Dichloro-4-fluorobenzene → 7-(3,4-Dichlorophenyloxy)-5-(2-fluoroethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride

HRID 1511632Notes

Reaction equation

HRID 1511632 reaction equation
[F:1][CH2:2][CH2:3][N:4]1[CH2:9][CH:8]([OH:10])[C:7]2[S:11][CH:12]=[CH:13][C:6]=2[CH2:5]1.[Cl:14][C:15]1[CH:16]=[C:17](F)[CH:18]=[CH:19][C:20]=1[Cl:21]>>[ClH:14].[Cl:14][C:15]1[CH:16]=[C:17]([O:10][CH:8]2[CH2:9][N:4]([CH2:3][CH2:2][F:1])[CH2:5][C:6]3[CH:13]=[CH:12][S:11][C:7]2=3)[CH:18]=[CH:19][C:20]=1[Cl:21]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 866392285-(2-Fluoroethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol

Product 1

HCID 866392297-(3,4-Dichlorophenyloxy)-5-(2-fluoroethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride

Procedure

The same method as in Reference Example 3 was conducted using 5-(2-fluoroethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 17) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-f52f469de387400186973495dd37845c
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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