Benzene, 1,2-dichloro-3-fluoro- → 8-(2,3-Dichlorophenyloxy)-5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepine

HRID 1511688Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1511688
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[O:10][CH:11]=[CH:12][C:4]=2[CH2:3]1.[Cl:13][C:14]1[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][C:15]=1F>>[Cl:13][C:14]1[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][C:15]=1[O:9][CH:6]1[CH2:7][CH2:8][N:2]([CH3:1])[CH2:3][C:4]2[CH:12]=[CH:11][O:10][C:5]1=2

Komponenten

3

Edukt 2

HCID 119011Benzene, 1,2-dichloro-3-fluoro-HCID 684099105-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepin-8-ol

Produkt 1

HCID 250277998-(2,3-Dichlorophenyloxy)-5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepine

Versuchsvorschrift

The same method as in Example 1 was conducted using 5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepin-8-ol (Reference Example 21) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,3-dichloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Aufarbeitung

  1. customto give the objective compound

Quellen und Nachweise

ORD-Eintrag
ord-3178b58cb8fc4e2297f6e85dfa476c43
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217031B2

Notizen zur Reaktion

Wird geladen…