1,2-Dibromo-4-fluorobenzene → 4-(3,4-Dibromophenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine

HRID 1511691ノート

反応式

HRID 1511691 の反応式
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[CH:10]=[CH:11][O:12][C:4]=2[CH2:3]1.[Br:13][C:14]1[CH:15]=[C:16](F)[CH:17]=[CH:18][C:19]=1[Br:20]>>[Br:13][C:14]1[CH:15]=[C:16]([O:9][CH:6]2[CH2:7][CH2:8][N:2]([CH3:1])[CH2:3][C:4]3[O:12][CH:11]=[CH:10][C:5]2=3)[CH:17]=[CH:18][C:19]=1[Br:20]

参加物

3

反応物 2

HCID 754021,2-Dibromo-4-fluorobenzeneHCID 684096967-Methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol

生成物 1

HCID 684223954-(3,4-Dibromophenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine

実験手順

The same method as in Example 1 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 19) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dibromo-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

後処理

  1. customto give the objective compound

出典と根拠

ORDレコード
ord-aff1ec84bceb4871a7b7db5bafeb7d6d
出典データセット
uspto-grants-2012_07
特許番号
US08217031B2

反応ノート

読み込み中…