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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1511691Generated: October 26, 2026

1,2-Dibromo-4-fluorobenzene → 4-(3,4-Dibromophenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine

https://huagongshe.com/reaction/1511691

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-Dibromo-4-fluorobenzeneHCID 75402—
Reactant7-Methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-olHCID 68409696—
Product4-(3,4-Dibromophenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepineHCID 68422395—

Reaction Steps

The same method as in Example 1 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 19) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dibromo-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217031B2
Source datasetuspto-grants-2012_07
ORD IDord-aff1ec84bceb4871a7b7db5bafeb7d6d
Source noteuspto-grants-2012_07