1-Chloro-3-fluoro-2-(trifluoromethyl)benzene → 4-[3-Chloro-2-(trifluoromethyl)phenyloxy]-7-methyl-5,6,7,8-tetrahydro-4h-furo[2,3-c]azepine

HRID 1511697Notes

Reaction equation

HRID 1511697 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[CH:10]=[CH:11][O:12][C:4]=2[CH2:3]1.[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16](F)[C:15]=1[C:21]([F:24])([F:23])[F:22]>>[Cl:13][C:14]1[C:15]([C:21]([F:22])([F:23])[F:24])=[C:16]([O:9][CH:6]2[CH2:7][CH2:8][N:2]([CH3:1])[CH2:3][C:4]3[O:12][CH:11]=[CH:10][C:5]2=3)[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 167439801-Chloro-3-fluoro-2-(trifluoromethyl)benzeneHCID 684096967-Methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol

Product 1

HCID 684217574-[3-Chloro-2-(trifluoromethyl)phenyloxy]-7-methyl-5,6,7,8-tetrahydro-4h-furo[2,3-c]azepine

Procedure

The same method as in Example 1 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 19) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2-chloro-6-fluorobenzotrifluoride instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-1951fdb757f7452792e06d7a8f8acef8
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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