1-Chloro-3-fluoro-2-(trifluoromethyl)benzene → 4-[3-Chloro-2-(trifluoromethyl)phenyloxy]-7-methyl-5,6,7,8-tetrahydro-4h-furo[2,3-c]azepine

Participants

Reaction Steps

The same method as in Example 1 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 19) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2-chloro-6-fluorobenzotrifluoride instead of 1-fluoronaphthalene to give the objective compound.

Provenance & Evidence