1-(2-Chloro-6-fluorophenyl)ethan-1-one → 4-(2-Acetyl-3-chlorophenyloxy)-6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine hydrochloride

HRID 1511698Notes

Reaction equation

HRID 1511698 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]([OH:8])[C:5]2[CH:9]=[CH:10][O:11][C:4]=2[CH2:3]1.[CH3:12][C:13]([C:15]1[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=1F)=[O:14]>>[ClH:21].[C:13]([C:15]1[C:20]([Cl:21])=[CH:19][CH:18]=[CH:17][C:16]=1[O:8][CH:6]1[CH2:7][N:2]([CH3:1])[CH2:3][C:4]2[O:11][CH:10]=[CH:9][C:5]1=2)(=[O:14])[CH3:12]

Participants

3

Reactant 2

HCID 27735781-(2-Chloro-6-fluorophenyl)ethan-1-oneHCID 133651566-Methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol

Product 1

HCID 684108724-(2-Acetyl-3-chlorophenyloxy)-6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine hydrochloride

Procedure

The same method as in Example 3 was conducted using 6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 1) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2-chloro-6-fluoroacetophenone instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-8aa904eaf1844663bd0ac7096b8f64f7
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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