1-(2-Chloro-6-fluorophenyl)ethan-1-one → 4-(2-Acetyl-3-chlorophenyloxy)-6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine hydrochloride

Participants

Reaction Steps

The same method as in Example 3 was conducted using 6-methyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridin-4-ol (Reference Example 1) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2-chloro-6-fluoroacetophenone instead of 1,3-difluorobenzene to give the objective compound.

Provenance & Evidence