Citric Acid → 8-(3,4-Dichlorophenyloxy)-5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepine citrate

HRID 1511714Notes

Reaction equation

HRID 1511714 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([O:9][CH:10]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][C:12]3[CH:18]=[CH:19][O:20][C:11]2=3)[CH:5]=[CH:6][C:7]=1[Cl:8].[C:21]([OH:33])(=[O:32])[CH2:22][C:23]([CH2:28][C:29]([OH:31])=[O:30])([C:25]([OH:27])=[O:26])[OH:24]>CO>[C:21]([OH:33])(=[O:32])[CH2:22][C:23]([CH2:28][C:29]([OH:31])=[O:30])([C:25]([OH:27])=[O:26])[OH:24].[Cl:1][C:2]1[CH:3]=[C:4]([O:9][CH:10]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][C:12]3[CH:18]=[CH:19][O:20][C:11]2=3)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 311Citric AcidHCID 684093368-(3,4-Dichlorophenyloxy)-5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepine

Product 1

HCID 684093358-(3,4-Dichlorophenyloxy)-5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepine citrate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The free body of 8-(3,4-dichlorophenyloxy)-5-methyl-5,6,7,8-tetrahydro-4H-furo[3,2-c]azepine provided with Example 158 was dissolved in methanol, and then into the resulting methanol solution was added 1 equivalent of citric acid and was stirred for 1 hour. The mixture was concentrated to give the objective compound.

Workup

  1. concentrationThe mixture was concentrated
  2. customto give the objective compound

Sources & evidence

ORD record
ord-0419533ca59045f690a0f301972099d9
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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