3-Chloro-4-fluorobenzamide → 4-(2-Chloro-4-carbamoylphenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride

HRID 1511717Notes

Reaction equation

HRID 1511717 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH:6]([OH:9])[C:5]2[CH:10]=[CH:11][O:12][C:4]=2[CH2:3]1.[C:13]([C:16]1[CH:21]=[CH:20][C:19](F)=[C:18]([Cl:23])[CH:17]=1)(=[O:15])[NH2:14]>>[ClH:23].[Cl:23][C:18]1[CH:17]=[C:16]([C:13](=[O:15])[NH2:14])[CH:21]=[CH:20][C:19]=1[O:9][CH:6]1[CH2:7][CH2:8][N:2]([CH3:1])[CH2:3][C:4]2[O:12][CH:11]=[CH:10][C:5]1=2

Participants

3

Reactant 2

HCID 27365203-Chloro-4-fluorobenzamideHCID 684096967-Methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol

Product 1

HCID 684114974-(2-Chloro-4-carbamoylphenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride

Procedure

The same method as in Example 3 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 19) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-carbamoyl-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-0b0c6b86df45474b9f54a6eb41499e8f
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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