Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Chloro-4-fluorobenzamide → 4-(2-Chloro-4-carbamoylphenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Chloro-4-fluorobenzamide | HCID 2736520 | — |
| 반응물 | 7-Methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol | HCID 68409696 | — |
| 생성물 | 4-(2-Chloro-4-carbamoylphenyloxy)-7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride | HCID 68411497 | — |
반응 단계
The same method as in Example 3 was conducted using 7-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 19) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-carbamoyl-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08217031B2 |
| 출처 데이터셋 | uspto-grants-2012_07 |
| ORD ID | ord-0b0c6b86df45474b9f54a6eb41499e8f |
| 출처 메모 | uspto-grants-2012_07 |