1-Bromo-2,5-dichloro-3-fluorobenzene → 4-(3-Bromo-2,5-dichlorophenyloxy)-2-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride

HRID 1511740Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1511740
[CH3:1][C:2]1[O:12][C:5]2[CH2:6][NH:7][CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=1.[Br:13][C:14]1[C:15]([Cl:22])=[C:16](F)[CH:17]=[C:18]([Cl:20])[CH:19]=1>>[ClH:20].[Br:13][C:14]1[C:15]([Cl:22])=[C:16]([O:11][CH:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]3[O:12][C:2]([CH3:1])=[CH:3][C:4]2=3)[CH:17]=[C:18]([Cl:20])[CH:19]=1

Komponenten

3

Edukt 2

HCID 6185131-Bromo-2,5-dichloro-3-fluorobenzeneHCID 684100692-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol

Produkt 1

HCID 684105464-(3-Bromo-2,5-dichlorophenyloxy)-2-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride

Versuchsvorschrift

The same method as in Example 3 was conducted using 2-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 44) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-bromo-2,5-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Aufarbeitung

  1. customto give the objective compound

Quellen und Nachweise

ORD-Eintrag
ord-31a554e0c7b34b5690d656152ecd6edc
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217031B2

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