1-Cyano-4-fluoronaphthalene → 7-(4-Cyanonaphthalen-1-yloxy)-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

HRID 1511747Notes

Reaction equation

HRID 1511747 reaction equation
[CH3:1][C:2]1[S:10][C:9]2[CH:8]([OH:11])[CH2:7][NH:6][CH2:5][C:4]=2[CH:3]=1.[C:12]([C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17](F)=[CH:16][CH:15]=1)#[N:13]>>[C:12]([C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]([O:11][CH:8]2[CH2:7][NH:6][CH2:5][C:4]3[CH:3]=[C:2]([CH3:1])[S:10][C:9]2=3)=[CH:16][CH:15]=1)#[N:13]

Participants

3

Reactant 2

HCID 27367341-Cyano-4-fluoronaphthaleneHCID 684104592-Methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol

Product 1

HCID 684111807-(4-Cyanonaphthalen-1-yloxy)-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

Procedure

The same method as in Example 1 was conducted using 2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 30) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-cyano-1-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-40d4a5734349471b87383da0c9b430ad
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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