1,2-Dichloro-4-fluorobenzene → 4-(3,4-Dichlorophenyloxy)-2,7-dimethyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine

HRID 1511753Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1511753
[CH3:1][C:2]1[S:13][C:5]2[CH2:6][N:7]([CH3:12])[CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=1.[Cl:14][C:15]1[CH:16]=[C:17](F)[CH:18]=[CH:19][C:20]=1[Cl:21]>>[Cl:14][C:15]1[CH:16]=[C:17]([O:11][CH:10]2[CH2:9][CH2:8][N:7]([CH3:12])[CH2:6][C:5]3[S:13][C:2]([CH3:1])=[CH:3][C:4]2=3)[CH:18]=[CH:19][C:20]=1[Cl:21]

Komponenten

3

Edukt 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 684098842,7-dimethyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol

Produkt 1

HCID 684109154-(3,4-Dichlorophenyloxy)-2,7-dimethyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine

Versuchsvorschrift

The same method as in Example 1 was conducted using 2,7-dimethyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol (Reference Example 23) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Aufarbeitung

  1. customto give the objective compound

Quellen und Nachweise

ORD-Eintrag
ord-e27270e06c694dfe862a3c0b229078ee
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08217031B2

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