1-Bromo-2-chloro-3-fluorobenzene → 7-(3-Bromo-2-chlorophenyloxy)-4,5,6,7-tetrahydrofuro[3,2-c]pyridine

HRID 1511769Notes

Reaction equation

HRID 1511769 reaction equation
[O:1]1[C:9]2[CH:8]([OH:10])[CH2:7][NH:6][CH2:5][C:4]=2[CH:3]=[CH:2]1.[Br:11][C:12]1[C:13]([Cl:19])=[C:14](F)[CH:15]=[CH:16][CH:17]=1>>[Br:11][C:12]1[C:13]([Cl:19])=[C:14]([O:10][CH:8]2[CH2:7][NH:6][CH2:5][C:4]3[CH:3]=[CH:2][O:1][C:9]2=3)[CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 37393011-Bromo-2-chloro-3-fluorobenzeneHCID 553001594,5,6,7-Tetrahydrofuro[3,2-c]pyridin-7-ol

Product 1

HCID 684121737-(3-Bromo-2-chlorophenyloxy)-4,5,6,7-tetrahydrofuro[3,2-c]pyridine

Procedure

The same method as in Example 1 was conducted using 4,5,6,7-tetrahydrofuro[3,2-c]pyridin-7-ol (Reference Example 33) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-bromo-2-chloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-44cc1f0a424f4fe2b0e316f205331155
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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