1-Cyano-4-fluoronaphthalene → 7-(4-Cyanonaphthalen-1-yloxy)-4,5,6,7-tetrahydrofuro[3,2-c]pyridine

HRID 1511772Notes

Reaction equation

HRID 1511772 reaction equation
[O:1]1[C:9]2[CH:8]([OH:10])[CH2:7][NH:6][CH2:5][C:4]=2[CH:3]=[CH:2]1.[C:11]([C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16](F)=[CH:15][CH:14]=1)#[N:12]>>[C:11]([C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]([O:10][CH:8]2[CH2:7][NH:6][CH2:5][C:4]3[CH:3]=[CH:2][O:1][C:9]2=3)=[CH:15][CH:14]=1)#[N:12]

Participants

3

Reactant 2

HCID 27367341-Cyano-4-fluoronaphthaleneHCID 553001594,5,6,7-Tetrahydrofuro[3,2-c]pyridin-7-ol

Product 1

HCID 684237977-(4-Cyanonaphthalen-1-yloxy)-4,5,6,7-tetrahydrofuro[3,2-c]pyridine

Procedure

The same method as in Example 1 was conducted using 4,5,6,7-tetrahydrofuro[3,2-c]pyridin-7-ol (Reference Example 33) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-cyano-1-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-4ac7daa2172b4705b1641fc633dc925c
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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