Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1511772Generated: November 4, 2026

1-Cyano-4-fluoronaphthalene → 7-(4-Cyanonaphthalen-1-yloxy)-4,5,6,7-tetrahydrofuro[3,2-c]pyridine

https://huagongshe.com/reaction/1511772

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyano-4-fluoronaphthaleneHCID 2736734—
Reactant4,5,6,7-Tetrahydrofuro[3,2-c]pyridin-7-olHCID 55300159—
Product7-(4-Cyanonaphthalen-1-yloxy)-4,5,6,7-tetrahydrofuro[3,2-c]pyridineHCID 68423797—

Reaction Steps

The same method as in Example 1 was conducted using 4,5,6,7-tetrahydrofuro[3,2-c]pyridin-7-ol (Reference Example 33) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-cyano-1-fluoronaphthalene instead of 1-fluoronaphthalene to give the objective compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217031B2
Source datasetuspto-grants-2012_07
ORD IDord-4ac7daa2172b4705b1641fc633dc925c
Source noteuspto-grants-2012_07