反应详情

温度

50 °C

LiClO4 (6.31 g, 60 mmol) was added to a solution of (RS)-tert-butyl-dimethyl-(2-oxiranyl-ethoxy)-silane (4 g, 20 mmol, prepared according to Heterocycles (1987), 25(1), 329-32) in MeCN (60 mL). 3-Fluoro-4-methylaniline (2.28 g, 18 mmol) was added and the mixture was stirred at 50° C. for 5 h. The solvent was removed under reduced pressure and the residue was purified by CC (DCM/MeOH/NH4OH 1000:25:2) to afford the title intermediate as brown oil (5.56 g, 86%).

1. customThe solvent was removed under reduced pressure
2. customthe residue was purified by CC (DCM/MeOH/NH4OH 1000:25:2)