(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine → (S)-1-(6-Methoxy-quinolin-4-yl)-pyrrolidin-3-ylamine

HRID 1511810노트

반응식

HRID 1511810 반응식
C(OC(=O)[NH:7][C@H:8]1[CH2:12][CH2:11][NH:10][CH2:9]1)(C)(C)C.Br[C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[CH:17][CH:16]=1>>[CH3:26][O:25][C:22]1[CH:23]=[C:24]2[C:19](=[CH:20][CH:21]=1)[N:18]=[CH:17][CH:16]=[C:15]2[N:10]1[CH2:11][CH2:12][C@H:8]([NH2:7])[CH2:9]1

참가 물질

3

반응물 2

HCID 1514396(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 111607474-Bromo-6-methoxyquinoline

생성물 1

HCID 66954035(S)-1-(6-Methoxy-quinolin-4-yl)-pyrrolidin-3-ylamine

실험 절차

Starting from (S)-pyrrolidin-3-yl-carbamic acid tert-butyl ester (commercial) and 4-bromo-6-methoxy-quinoline (commercial) the title compound was prepared according to procedure F followed by procedure E and was isolated as a brown oil (801 mg, 78% over two steps).

출처 및 근거

ORD 기록
ord-5fef4682c19e414c95ca18ccceb32b91
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08217029B2

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