Hydrochloric Acid → HCID 58881771, compound

HRID 1511824Notes

Reaction equation

HRID 1511824 reaction equation
[Si]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]([NH:16][C:17]1[CH:18]=[CH:19][C:20]2[C:21]([N:32]=1)=[N:22][C:23]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[CH:24][N:25]=2)=[O:15])(C(C)(C)C)(C)C.Cl>ClCCl>[OH:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]([NH:16][C:17]1[CH:18]=[CH:19][C:20]2[C:21]([N:32]=1)=[N:22][C:23]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[CH:24][N:25]=2)=[O:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 16727344HCID 16727344, compound

Product 1

HCID 58881771HCID 58881771, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

360 mg (0.22 mmol) of 1-[4-(tert-butyldimethylsilanyloxy)butyl]-3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea were dissolved in 20 ml of dichloromethane and admixed with 5 ml of a 2 molar isopropanolic HCl solution. After stirring at room temperature for 12 h, the reaction mixture was washed with water and dried (Na2SO4). Removal of the solvent under reduced pressure afforded a bright yellow solid.

Workup

  1. washthe reaction mixture was washed with water
  2. dry with materialdried (Na2SO4)
  3. customRemoval of the solvent under reduced pressure
  4. customafforded a bright yellow solid

Sources & evidence

ORD record
ord-ae53012596ef41efaa46a07cc044c3d3
Source dataset
uspto-grants-2012_07
Patent number
US08217042B2

Reaction notes

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