反应详情

A 250 ml three-necked round-bottomed flask equipped with temperature probe and nitrogen bubbler was charged with 1M Borane/THF solution (60.4 ml, 60.4 m mol) and a solution of (3-Methoxy-phenoxy)-acetic acid (5.00 g, 27.4 mmol) in THF (2.0 ml) was added dropwise, maintaining reaction temperature below 30° C. The reaction was allowed to stir at room temperature overnight. The reaction was quenched by dropwise addition of methanol (20 ml) maintaining the reaction temperature below 35° C. The reaction was stirred at room temperature for 4 hours and concentrated under reduced pressure to yield 2-(3-Methoxy-phenoxy)-ethanol (4.51 g, 98%) as a clear oil which was used without further purification.

1. customA 250 ml three-necked round-bottomed flask equipped with temperature probe and nitrogen bubbler
2. temperaturemaintaining
3. customreaction temperature below 30° C
4. customThe reaction was quenched by dropwise addition of methanol (20 ml)
5. temperaturemaintaining the reaction temperature below 35° C
6. stirringThe reaction was stirred at room temperature for 4 hours
7. concentrationconcentrated under reduced pressure