反应详情

温度

100 °C

To a slurry of silica gel (1 g) and copper sulfate hydrate (1 g) in toluene (10 mL) was added (5R,7R)-7-(4-(7-hydroxy-7-methyloctyl)phenyl)-3-oxa-1-azaspiro[4.4]nonan-2-one (230 mg, 0.640 mmol). The reaction mixture was heated to 100° C. After 2 days Na2SO4 (approx. 500 mg) was added. After an additional 1 day at 100° C. the reaction mixture was cooled to room temperature and filtered, rinsing with EtOAc. The resulting alkene was added to a slurry of palladium hydroxide on carbon (4.49 mg, 0.032 mmol) in MeOH (10.00 mL). Hydrogen was bubbled through the solution for 5 min and an atmosphere of hydrogen was maintained via balloon. After 15 h the reaction mixture was filtered and concentrated in vacuo. The crude alkane was purified by chromatography on silica gel (EtOAc/Hep) to provide (5R,7R)-7-(4-(7-methyloctyl)phenyl)-3-oxa-1-azaspiro[4.4]nonan-2-one (120 mg, 0.349 mmol, 54.6% yield) as a colorless solid.

1. temperatureAfter an additional 1 day at 100° C. the reaction mixture was cooled to room temperature
2. filtrationfiltered
3. washrinsing with EtOAc
4. customHydrogen was bubbled through the solution for 5 min
5. temperaturean atmosphere of hydrogen was maintained via balloon
6. filtrationAfter 15 h the reaction mixture was filtered
7. concentrationconcentrated in vacuo
8. customThe crude alkane was purified by chromatography on silica gel (EtOAc/Hep)