反应详情

温度

80 °C

3-(4-Octyl-phenyl)-cyclopentanone, malonic acid (0.076 g, 0.734 mmol), ammonium acetate (0.057 g, 0.734 mmol) were suspended in the mixture of ethanol (1.50 mL, 25.7 mmol) and methanol (0.50 mL, 12.36 mmol) in a 15-mL, 2-necked round-bottomed flask equipped with a condenser. The heterogeneous mixture was heated to reflux at 80° C. for about 24 hours. Heating was removed. The crude mixture was taken up in dichloromethane/water mixture (20 mL/20 mL). The resulting fine suspension was filtered, washed several times with water and dichloromethane, and vacuum-dried to yield 2-(1-amino-3-(4-octylphenyl)cyclopentyl)acetic acid (0.020 g, 0.060 mmol) as off-white solid.

1. customequipped with a condenser
2. temperatureThe heterogeneous mixture was heated
3. temperatureHeating
4. customwas removed
5. filtrationThe resulting fine suspension was filtered
6. washwashed several times with water and dichloromethane
7. customvacuum-dried