Sodium hydride → HCID 67229920, compound

HRID 1511924Notes

Reaction equation

HRID 1511924 reaction equation
[C:1]([O:5][C:6](=[O:13])[NH:7][N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)([CH3:4])([CH3:3])[CH3:2].[F:14][C:15]1[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:16]=1[CH2:17]Br.[H-].[Na+]>>[C:1]([O:5][C:6](=[O:13])[N:7]([CH2:17][C:16]1[CH:19]=[CH:20][C:21]([F:23])=[CH:22][C:15]=1[F:14])[N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 902971-(Bromomethyl)-2,4-difluorobenzeneHCID 49760548tert-Butyl 1H-pyrrol-1-ylcarbamate

Product 1

HCID 67229920HCID 67229920, compound

Procedure

Prepared according to the benzylation condition used in Example 1 step b) from pyrrol-1-yl-carbamic acid tert-butyl ester (1.0 eq.), 2,4-difluorobenzyl bromide (1.03 eq.) and sodium hydride (1.3 eq.). ESI (m/z): 309 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-623215c570264e36b7989a4d30b9392e
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

Loading…